Thus far my favorite 360 games have been Halo 3 and GTA IV.
I have Fable 2 and have enjoyed what I've played of it so far, however I am only just now at the part where you become an adult.
I also have Mass Effect and am very much looking forward to playing it. I want to finish the other games first though.
I want to play Mass Effect, but I can't stand first person games. The reason I want to play it though is because it was mentioned in the last issue of GameInformer as the best RPG for dialog. I love good dialog in a game so that would be the reason I would want to play it.
I would urge you to go ahead and give it a shot. From what I've come to understand Mass Effect plays primarily in third-person but controls similarly to a first-person game (somewhat like RE4). I believe that there are first-person controls for certain circumstances such as aiming a sniper rifle.
I wanted to play Mass Effect largely because Knights of the Old Republic is by far my favorite RPG. Even without the Star Wars connection it is an amazing game. I never got a chance to play Jade Empire, but since Bioware did such an amazing job on KOTOR I figure that Mass Effect will be awesome as well.